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Results for "

5-LOX Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lipoxygenase (23) LOX-1 (1) Apoptosis (2) Autophagy (1) Bacterial (1) Carbonic Anhydrase (1) Caspase (1) COX (12) Epoxide Hydrolase (2) Ferroptosis (1) FLAP (4) Leukotriene Receptor (1) Notch (1) PGE synthase (2) Reactive Oxygen Species (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (26) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: LOX-1 Lipoxygenase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138939

5-LOX-IN-2	Lipoxygenase	Cancer
5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC₅₀ of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research .

HY-113807

ZLJ-6	COX Lipoxygenase	Inflammation/Immunology
ZLJ-6 is a dual COX and *5-LOX* inhibitor with oral activity. The IC₅₀ values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity .

HY-155407

ALR-6	FLAP	Inflammation/Immunology
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .

HY-149476

5-LOX-IN-5

Lipoxygenase Neurological Disease

5-LOX-IN-5 (Compound 29) is a 5-LOX inhibitor (IC₅₀: 56 nM). 5-LOX-IN-5 can be used for research of neurodegenerative diseases .

5-LOX-IN-5	Lipoxygenase	Neurological Disease
5-LOX-IN-5 (Compound 29) is a 5-LOX inhibitor (IC₅₀: 56 nM). 5-LOX-IN-5 can be used for research of neurodegenerative diseases .

HY-155408

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

HY-N9115

Plathymenin

Lipoxygenase Inflammation/Immunology

Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of 5-LOX .

Plathymenin	Lipoxygenase	Inflammation/Immunology
Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of *5-LOX* .

HY-117048

PF-4191834 PF-04191834	Lipoxygenase	Inflammation/Immunology
PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC₅₀=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain .

HY-148134

5-LOX-IN-1	Lipoxygenase	Inflammation/Immunology
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase *(5-LOX)* with an IC₅₀ value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .

HY-N0198

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Lipoxygenase Autophagy Ferroptosis	Neurological Disease Cancer
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-155409

ALR-38	Lipoxygenase	Inflammation/Immunology
ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC₅₀: 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils .

HY-146675

COX/5-LOX-IN-1	COX	Inflammation/Immunology
COX/5-LOX-IN-1 (compound 6b) is a potent and dual inhibitor of *COX/5-LOX* with IC₅₀s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectively. COX/5-LOX-IN-1 has the potential for the research of inflammation diseases .

HY-147951

COX-2/5-LOX-IN-3	COX Lipoxygenase	Inflammation/Immunology
COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual *COX-2/5-LOX* inhibitor with IC₅₀ values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases .

HY-N0232

Psoralidin 4 Publications Verification	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial	Cancer
Psoralidin is a dual inhibitor of COX-2 and *5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1* signaling. Psoralidin also greatly induces ROS generation .

HY-10439

HPGDS inhibitor 1	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

HY-121585

CAY10698	Lipoxygenase	Inflammation/Immunology
CAY10698 (compound 1) is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC₅₀ of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2 .

HY-105024

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC₅₀ values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .

HY-156329

sEH/FLAP-IN-1	Epoxide Hydrolase FLAP	Inflammation/Immunology
sEH/FLAP-IN-1 (Compound 46A) is a sEH/FLAP inhibitor. sEH/FLAP-IN-1 inhibits 5-LOX product formation in SACM-stimulated PBMCs (EC₅₀: 11 nM). sEH/FLAP-IN-1 inhibit sEH (EC₅₀: 18 nM) and thromboxane production. sEH/FLAP-IN-1 can be used for research of inflammatory diseases .

HY-A0060

Malotilate NKK 105	Lipoxygenase	Cancer
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC₅₀=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .

HY-B1452

Licofelone 1 Publications Verification ML-3000
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .

HY-146295

COX-2/5-LOX-IN-2	COX	Inflammation/Immunology
COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 5.40, 0.01 and 1.78 μM, respectively .

HY-146294

COX-2/5-LOX-IN-1	COX	Inflammation/Immunology
COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 12.13, 0.4 and 4.96 μM, respectively .

HY-128171

Diflapolin 1 Publications Verification	FLAP Epoxide Hydrolase	Inflammation/Immunology
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC₅₀s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC₅₀=20 nM) .

HY-N0551

Wedelolactone Maximum Cited Publications 14 Publications Verification	Caspase Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-B1452S1

Licofelone-d6 ML-3000-d₆	Apoptosis Lipoxygenase COX
Licofelone-d₆ is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].

HY-149270

COX-2-IN-31	COX	Inflammation/Immunology
COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC₅₀=60 nM) and *5-LOX* (IC₅₀=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(K_i=48.9 nM) and hCA XII(K_i=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity .

HY-111140

YS121	PGE synthase Lipoxygenase	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀=3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC₅₀=12 μM in IL-1β-stimulated A549 cells .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-N1942

5-O-Demethylnobiletin 1 Publications Verification 5-Demethylnobiletin
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-125975

1-Naphthyl 3,5-dinitrobenzoate	Lipoxygenase	Inflammation/Immunology
1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC₅₀ values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC₅₀ value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation .

HY-111310

ML351	Lipoxygenase	Neurological Disease Metabolic Disease
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC₅₀ of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .

HY-149269

COX-2-IN-30	COX Carbonic Anhydrase LOX-1	Inflammation/Immunology
COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC₅₀=49 nM for COX-2, 10.4 μM for COX-1) and *5-LOX* (IC₅₀=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss K_i values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect .

HY-120502

5-LOX-IN-6	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC₅₀ values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research .

HY-153279

5-LOX-IN-3	Lipoxygenase	Neurological Disease Inflammation/Immunology Cancer
5-LOX-IN-3 (Compound 14) is a 5-Lipoxygenase inhibitor (IC₅₀: <1 μM). 5-LOX-IN-3 can be used for research of inflammatory diseases, cancer, stroke and Alzheimer's disease .

HY-N0493

Pectolinarigenin 1 Publications Verification	COX Lipoxygenase	Inflammation/Immunology
Pectolinarigenin is a dual inhibitor of *COX-2/5-LOX*. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .

HY-N8480

Atractylochromene

Lipoxygenase COX Inflammation/Immunology

Atractylochromene is a potent dual inhibitor of 5-LOX/COX-1 with IC₅₀s of 0.6 and 3.3 μM, respectively .
HY-U00308

5-LOX-IN-4

Lipoxygenase Cardiovascular Disease Inflammation/Immunology

5-LOX-IN-4 is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

Atractylochromene	Lipoxygenase COX	Inflammation/Immunology
Atractylochromene is a potent dual inhibitor of *5-LOX/COX-1* with IC₅₀s of 0.6 and 3.3 μM, respectively .

5-LOX-IN-4	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
5-LOX-IN-4 is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0198

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Lignans Plants other families Phenols Polyphenols Phenylpropanoids Disease Research Fields Cancer	Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-N0232

Psoralidin 4 Publications Verification	Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin is a dual inhibitor of COX-2 and *5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1* signaling. Psoralidin also greatly induces ROS generation .

HY-N0551

Wedelolactone Maximum Cited Publications 14 Publications Verification	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N0493

Pectolinarigenin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	COX Lipoxygenase
Pectolinarigenin is a dual inhibitor of *COX-2/5-LOX*. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .

HY-N9115

Plathymenin	Saussurea costus (Falc.) Lipsch. Structural Classification Flavonoids Flavones Leguminosae Source classification Plants	Lipoxygenase
Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of *5-LOX* .

HY-N8480

Atractylochromene	Structural Classification Natural Products Source classification Plants Compositae Erythrina sigmoidea Hua	Lipoxygenase COX
Atractylochromene is a potent dual inhibitor of *5-LOX/COX-1* with IC₅₀s of 0.6 and 3.3 μM, respectively .

Cat. No.	Product Name	Chemical Structure

HY-B1452S1

Licofelone-d6
Licofelone-d₆ is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].

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5-LOX Inhibitor

Inhibitors & Agonists

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Isotope-Labeled Compounds

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